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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  7

Year :  2013

Pages :   790-793

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and evaluation of topical gel of Meloxicam with Beta-Cyclodextrin complex.

Address:   Manoj M Nitalikar1*, Dinesh M. Sakarkar2
1Research Scholar, Department of Pharmaceutical sciences, Suresh Gyan Vihar University, Jaipur (India)
2Department of Pharmaceutics, Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist. Yavatmal, (India)
*Corresponding Author
DOI No: Not Available

Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. The present research has been undertaken with the aim to develop a topical gel formulation of Meloxicam, which would attenuate the gastrointestinal relater toxicities associated with oral administration. Meloxicam is a nonsteroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic activity through inhibition of prostaglandinsynthetase, via inhibition of cyclooxygenase enzymes. This study was designed to enhance the solubility of Meloxicam by preparing its inclusion complex with Beta-cyclodextrin and formulating gels using Carbopol 940 and HPMC E 6. The gels were evaluated for release through goat abdominal skin. It was observed that the formulation containing complex (DCG 2) was good in all respects.
Meloxicam, Beta-cyclodextrin, Meloxicam-Beta-CD-Complex, gel, goat abdominal skin.
Manoj M Nitalikar, Dinesh M. Sakarkar. Formulation and evaluation of topical gel of Meloxicam with Beta-Cyclodextrin complex. Research J. Pharm. and Tech 6(7): July 2013; Page 790-793.
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