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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   659-661

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of RP-HPLC Method for Estimation of Risperidone in Tablet Dosage Form



Address:   Alivelu Samala1*, Santhosh Pawar1, Sowmya Manala2, Sravanthi Chada1 and Nageshwar M.1
1Dept. of Pharmaceutical Chemistry, Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda, Ghatkesar, Ranga Reddy District,500088, A.P, India.
2Dept. of Pharmaceutical Analysis, Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda, Ghatkesar, Ranga Reddy District,500088, A.P, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, specific, reproducible and accurate reverse-phase HPLC method was developed and validated for estimation of an antipsychotic drug, Risperidone in tablet dosage form. The separation was achieved by Thermo C18 (250mm x 4.6mm, 5µm particle size) using acetonitrile and 0.2M potassium dihydrogen phosphate (80:20v/v) as an eluent, at a flow rate of 0.7mL/min. The injection volume was 20µl and the detection was carried out at wavelength 254nm. The retention time of Risperidone was 5.68min. The linearity was found to be in the concentration range of 2-10µg/ml with a correlation coefficient (r2) of 0.9982. The mean recovery was found to be in the range of 99.7-100.3%. The % RSD value was below 2 for intraday and interday precision indicated the present method was precise. Hence the proposed method can be used for routine analysis of Risperidone in tablet dosage form.
KEYWORDS:
Risperidone, RP-HPLC, Estimation, Validation.
Cite:
Alivelu Samala, Santhosh Pawar, Sowmya Manala, Sravanthi Chada, Nageshwar M. Development and Validation of RP-HPLC Method for Estimation of Risperidone in Tablet Dosage Form. Research J. Pharm. and Tech 6(6): June 2013; Page 659-661.
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