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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   655-658

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Super Porous Hydrogel Composites of Metoprolol Tartrate



Address:   A. K. Patel1*, Raj K. Prasad1, S. S. Gautam1, Omprakash2
1Shambhunath Institute of Pharmacy, Jhalwa, Near IIIT, Allahabad, U.P., India-211012
2R. K. G. Institute of Pharmacy, Gaziabad, U. P., India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The purpose of this study was to develop formulations and systematically evaluate in vitro performances of super porous hydrogel composites of Metoprolol Tartrate. A cross-over design was employed in formulating the SPHC with variation in polymer concentration (N, N-methylene-bisacrylamide (1-3%) and Ac-Di-Sol (200-300mg)). Study the effect of variation on swelling time, mechanical properties and in vitro drug release. The result shows that increase in Ac-Di-Sol concentration also increase in mechanical strength where as 2% of Bis concentration have less swelling time. In-vitro release data show that best result at optimum concentration of Bis (2%) and Ac-Di-Sol concentration (250mg).
KEYWORDS:
Super porous hydrogels, Cross over design, Metoprolol tartrate, Ac-Di-Sol.
Cite:
A. K. Patel, Raj K. Prasad, S. S. Gautam, Omprakash. Formulation and Evaluation of Super Porous Hydrogel Composites of Metoprolol Tartrate. Research J. Pharm. and Tech 6(6): June 2013; Page655-658.
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