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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  6

Year :  2013

Pages :   685-687

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Accelerated Recovery of 5-Fluorouracil-Damaged Bone Marrow after Oxytocin Treatment



Address:   Shadan Muslim Aljanabi1*, Shaza Al-Laham1, Adnan M. Ekhtiar2
1Pharmacology Department, Collage of Pharmacy, Damascus University, Syria
2Biotechnology Department, Syrian Atomic Energy Commission, Syria
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Our preliminary data indicate that Oxytocin may be myeloprotective. We investigated whether it can modify bone marrow recovery. Oxytocin (150 µg/kg) accelerated the recovery of the number of medium size cells (MI%) and platelets (PLT) but did not affect the number of circulating red blood cells (RBC) and total count of white blood cells (WBC).Oxytocin injected subcutaneously for 5 consecutive days at doses of 150 µg/kg (twice a day) after 5-FU single dose. Glutathione GSH (anti-oxidant) has preventive effects against 5-FU-induced myelosuppression and can accelerate recovery of bone marrow. Oxytocin only increase GSH levels insignificantly (P > 0.05).These findings suggest that Oxytocinselectively enhances the recovery of the population of progenitor cells reduced by 5-FU in rats.
KEYWORDS:
Oxytocin, Myeloprotective, Medium size cells, 5-Fluorouracil.
Cite:
Shadan Muslim Aljanabi, Shaza Al-Laham, Adnan M. Ekhtiar. Accelerated Recovery of 5-Fluorouracil-Damaged Bone Marrow after Oxytocin Treatment. Research J. Pharm. and Tech 6(6): June 2013; Page 685-687.
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