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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  5

Year :  2013

Pages :   553-555

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Analytical Methods for Lacosamide

Address:   Jane J.*, Dhaval Ladani
Associate Professor, Dept of Pharma Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte-575018, Mangalore
*Corresponding Author
DOI No: Not Available

Lacosamide is an anti epileptic drug, for which, two simple, sensitive, accurate, precise, and economical methods (method 1 and 2) have been developed for the quantitative estimation of Lacosamide in bulk and pharmaceutical formulation. Method-1 is a simple, accurate and sensitive HPLC method and the chromatographic separation was carried out on C8 column Welchrom (250 × 4.6mm, 5µ.) using a mobile phase composition of potassium dihydrogen phosphate buffer: acetonitrile (850:150 v/v) pumped at flow rate of 1.5 ml/min. The eluent was monitored at 215 nm with a diode array detector. Method-2 was based on condensation reaction between Lacosamide and vanillin in presence of conc. Sulphuric acid involving the formation of violet colored chromogen which showed linearity in the range 100-500µg/ml at a lambda max of 613 nm. The methods were statistically validated for precision, accuracy, robustness and recovery as per ICH guidelines
Lacosamide, Spectrophotometry, HPLC.
Jane J., Dhaval Ladani. Development and Validation of Analytical Methods for Lacosamide. Research J. Pharm. and Tech. 6(5): May 2013; Page 553-555.
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