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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  4

Year :  2013

Pages :   363-365

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Estimation of Faropenem in bulk and in Pharmaceutical Formulations



Address:   D. Jyothsna*, Dr. K. Vanitha Prakash, Anusha Dacha, Sabahath Ameena, Shaik Riaz
SSJ College of Pharmacy, Department of Pharmaceutical Analysis and Quality Assurance, V.N. Pally, Gandipet, Hyderabad- 500075 (India)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, economical, precise, reliable and reproducible Visible Spectrophotometric Method has been developed for the estimation of Faropenem in bulk as well as in tablet formulations. The method is based on the formation of blue colored chromogen, when the drug reacts with Folin-Ciocalteu (F-C) reagent in alkaline medium. The colored species has an absorption maximum at 745 nm and obeys Beer’s law in the concentration range 50-300 mcg/mL. The apparent molar absorptivity and sandell’s sensitivity were 0.370x 103 and 0.587respectively. The slope and intercept of the equation of the regression line are 0.001 and 0.0479 respectively. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Faropenem in pharmaceutical formulations.
KEYWORDS:
Faropenem, FC(folin-ciocalteu) reagent, Ultraviolet-Visible double beam- spectrophotometer, calibration curve, absorption spectrum.
Cite:
D. Jyothsna, K. Vanitha Prakash, Anusha Dacha, Sabahath Ameena, Shaik Riaz. Spectrophotometric Estimation of Faropenem in bulk and in Pharmaceutical Formulations. Research J. Pharm. and Tech. 6(4): April 2013; Page 363-365.
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