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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  4

Year :  2013

Pages :   360-362

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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IR Quantification of Alverine Citrate in Bulk and Oral Dosage Form



Address:   N. Oval, A. Jerad Suresh, V. Niraimathi *
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600003, Tamil Nadu, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Alverine is chemically N-Ethyl-3-phenyl-N-(3-phenylpropyl) propan-1-amine, commonly used as a smooth muscle relaxant, antispasmodic in irritable bowel syndrome and dysmenorrheal agent. A simple and sensitive Infrared spectrophotometric method has been developed for the estimation of alverine citrate in capsule dosage form. The Method involves the determination of alverine citrate by absorbance and peak area method of IR spectrophotometry. The sample was analyzed by KBr pellet method; IR band at 2052cm-1 was considered for quantification;. The calibration graph were plotted with a) absorbance against concentration b) area calculated by inbuilt software against concentration; The Beer’s law range was found to lie between 1-3mg. The correlation coefficient for the method was found to be 0.999 and the developed method was analyzed for specificity, limit of detection (LOD), limit of quantification (LOQ), linearity of response, precision and accuracy. Thus the proposed method could be adopted for routine analysis of bulk drug and its formulation
KEYWORDS:
Infrared spectroscopy (IR), Beer’s law, Limit Of Detection (LOD), Limit Of Quantification (LOQ).
Cite:
N. Oval, A. Jerad Suresh, V. Niraimathi . IR Quantification of Alverine Citrate in Bulk and Oral Dosage Form. Research J. Pharm. and Tech. 6(4): April 2013; Page 360-362.
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