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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  3

Year :  2013

Pages :   240-243

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Method development and validation of Rilpivirine in bulk and Tablet doses form by RP-HPLC method



Address:   Somsubhra Ghosh1*, Sowjanya Bomma1, V. Laxmi Prasanna1, S. Vidyadhar1, David Banji1, Subhadip Roy2
1Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, India, 508001.
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A new simple, accurate, rapid and precise isocratic High Performance Liquid Chromatographic (HPLC) method was developed and validated for the determination of Rilpivirine in bulk drug & its tablet doses form. The Method employs Waters HPLC system on C8 Column (4.6 x 250 mm, 5 µm) and flow rate of 1 ml/min with a load of 10µl. The Detection was carried out at 282 nm. mobile phase used as Acetonitrile and Phosphate buffer was used as mobile phase in the composition of 60:40, phosphate buffer adjusted the pH to 3.5, within a short runtime of 6 min. The retention times of Rilpivirine 2.75 min. The method was validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity and robustness etc.
KEYWORDS:
Rilpivirine, HPLC, Validation, Tablet doses form.
Cite:
Somsubhra Ghosh, Sowjanya Bomma, V. Laxmi Prasanna, S. Vidyadhar, David Banji, Subhadip Roy. Method development and validation of Rilpivirine in bulk and Tablet doses form by RP-HPLC method. Research J. Pharm. and Tech. 6(3): March 2013; Page 240-243.
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