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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  2

Year :  2013

Pages :   204-207

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and validation of RP-HPLC method for qunatitative analysis of Amlodipine besylate in pure and Pharmaceutical formulations



Address:   S. Chandra Dinda1, R.B. Desireddy2, P. Jitendra Kumar2*, A. Sai Chand2, P. Srinivasa Rao2, B. Ashok Kumar2,
1School of Pharmaceutical Education and Research, Berhampur University, Berhampur, Odhisa,
2Nalanda Institute of Pharmaceutical Sciences, Kantepudi (V), Guntur (A.P)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A Validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Amlodipine besylate in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250mm×4.6mm×5µ particle size) using Methanol: Acetonitrile: 0.01M Phosphoric acid (75:23:2) as mobile phase. Detection was carried out by U.V at 236nm. The proposed method obeyed linearity in the range of 10-100µg/ml and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Amlodipine besylate in pure and its formulations.
KEYWORDS:
Amlodipine besylate , C18 column, Reverse phase, Validation, Specificity.
Cite:
S. Chandra Dinda, R.B. Desireddy, P. Jitendra Kumar, A. Sai Chand, P. Srinivasa Rao, B. Ashok Kumar. Development and validation of RP-HPLC method for qunatitative analysis of Amlodipine besylate in pure and Pharmaceutical formulations. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 204-207.
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