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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  12

Year :  2013

Pages :   1380-1386

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Characterization of Enteric Coated Delayed Release Pellets of Rabeprazole Sodium



Address:   Y. Surekha, P. Venugopalaiah, K. Gnan Prakash and M. Gobinath
Department of Pharmaceutics, Ratnam Institute of Pharmacy, Nellore, Andhra Pradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Oral modified release multiple unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single unit dosage forms. The present study is to prepare Rabeprazole sodium delayed release pellets by using HPMC based sub coating and Methacrylic acid copolymer based enteric coating and to target the release of drug in intestine and to avoid stability related problems. Different batches of pellets were prepared by using drug suspension method. Comparative study of dissolution profile of final batch with market preparation was conducted and it was concluded that final batch shown good similarity with market product. The results of the accelerated stability of final formulation revealed that storage conditions were excellent.
KEYWORDS:
Rabeprazole sodium, delayed release, enteric coating.
Cite:
Y. Surkha, P. Venugopalaiah, K. Gnan Prakash, M. Gobinath. Design and Characterization of Enteric Coated Delayed Release Pellets of Rabeprazole Sodium. Research J. Pharm. and Tech. 6(12): Dec. 2013; Page 1380-1386.
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