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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  12

Year :  2013

Pages :   1430-1438

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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L-Arginase: a Medically Important Enzyme



Address:   Kuldeep Kumar1* and Neelam Verma2
1Department of Biotechnology, M.M. Modi College, Patiala-147 001 Punjab (India)
2Department of Biotechnology, Punjabi University, Patiala-147 002 Punjab (India)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
L-arginase also referred to as L-arginine amidinohydrolase (EC.3.5.3.1) catalyzes the hydrolysis of L-arginine into L-ornithine and urea which is the last step of urea cycle in liver of ureotelic species. This enzyme exists in two forms. The first one is arginase-1, is found in liver cells and second one is arginase-2 which is a mitochondrial enzyme that occurs mainly in extra hepatic tissues including kidney, brain and skeletal muscle. L-arginase consists of three tetramers. The present article comprises information on the enzyme L-arginase, which is used in the treatment of cancer. It is isolated from variety of sources such as bacterial cells, yeast cells, fungal cells and plant cells. The present review has discussed about the production of enzyme from different sources, method of assay, purification and characterization of enzyme including the structural information of L- arginase.
KEYWORDS:
L-arginine, amidinohydrolase, cancer, tetramers, sources.
Cite:
Kuldeep Kumar, Neelam Verma. L-Arginase: a Medically Important Enzyme. Research J. Pharm. and Tech. 6(12): Dec. 2013; Page 1430-1438.
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