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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  11

Year :  2013

Pages :   1242-1246

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation, Evaluation and Stability Studies for the Sustained Release Mucoadhesive Microcapsules of Gliclazide



Address:   1Nalanda college of Pharmacy, Nalgonda, 508001 2Global Data, Hyderabad 3A.S.N. Pharmacy College, Tenali
DOI No: Not Available

ABSTRACT:
Mucoadhesive microspheres interaction with the mucus layer covering the mucosal epithelial surface and increase the residence time of the spheres at the site of absorption or action. The present investigation is to formulate and evaluate mucoadhesive microspheres of Gliclazide by using Sodium CMC 200-300cps, Hydroxy Propyl Methyl Cellulose 50cps and Methyl Cellulose as mucoadhesive polymers. The Microspheres were prepared by the Emulsion Gelation method and the prepared microspheres were evaluated for flow properties, size analysis, wall thickness, drug content, SEM analysis, entrapment efficiency, mucoadhesive strength, In-vitro drug release and stability studies. The In-Vitro drug release was extended up to 12 hours and almost 42% and 27% of mucoadhesion was observed in 0.1N Hcl and pH 7.4 phosphate buffers respectively. The optimized formulation was found to be stable as per ICH guidelines.
KEYWORDS:
Gliclazide, Emulsion Gelation Method, Mucoadhesive Microspheres, Mucoadhesive polymers and Sustained Release.
Cite:
Praveen Kumar Reddy Thumma, P.N. Deepthi, B. Sudheer, Poreddy Praveen Reddy, Swathi Kandukuri, David Banji. Formulation, Evaluation and Stability Studies for the Sustained Release Mucoadhesive Microcapsules of Gliclazide. Research J. Pharm. and Tech. 6(11): November 2013; Page 1242-1246.
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