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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  11

Year :  2013

Pages :   1190-1194

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antiallergic, Antianaphylactic and Mast Cell Stabilizing, Activity of Embelia ribes brum.



Address:   Katare Varsha B.1*, Bhutkar M. A.1, Kumbhar A. P.1, Pol S. K.1, Katare P. B.2
1Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Dist. Sangli (Maharashtra)
2 NIPER, Balanagar, Hyderabad.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In the present study, the effect of ethanolic extract of fruit berries of Embelia ribes brum (ER) on milk induced leukocytosis and eosinophilia in mice, compound 48/80 induced mast cell degranulation in rats and egg albumin induced passive paw anaphylaxis in rats was done and in the animal model of milk induced leukocytosis and eosinophilia, ER showed significant decrease in difference in no. of leucocytes and eosinophils count. In the compound 48/80 induced mast cell degranulation in rats, ER showed significant decrease in no. of degranulated mast cells count and significant increase in no. of intact mast cells count. In egg albumin induced passive paw anaphylaxis in rats, ER showed significant reduction in the paw edema volume. Thus these results suggest us that ER may prove to be a potential therapeutic drug for treating allergic diseases such as allergic asthma and the result obtained in this study may be due to its adaptogenic, antistress, mast cell stabilizing, inhibition of AG: AB reaction and anti-inflammatory activities.
KEYWORDS:
Embelia ribes brum, degranulation, leukocytosis, eosinophilia, anaphylaxis.
Cite:
Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora. Antiallergic, Antianaphylactic and Mast Cell Stabilizing, Activity of Embelia ribes brum. Research J. Pharm. and Tech. 6(11): November 2013; Page 1190-1194.
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