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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  10

Year :  2013

Pages :   1124-1126

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Screening of Antiepileptic Activity of Leaves of Sapindus trifoliatus Linn.



Address:   Jennifer Fernandes*, Bhat K.Ishwar1, Fernandes Ronald2
*Professor, Dept. of Pharma. Chem., NGSM Institute of Pharmaceutical Sciences, Paneer-575018 India.
1Professor & Head, Dept of Pharma. Chem., N.G.S.M. Institute of Pharmaceutical Sciences, Paneer-575018 India
2Professor, Dept of Pharma. Chem., N.G.S.M. Institute of Pharmaceutical Sciences, Paneer-575018 India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aim of the present study was to investigate anticonvulsant effect of ethanolic extract of the leaves of Sapindus trifoliatus on electrically and chemically induced seizures. The ethanol extract of the leaves of Sapindus trifoliatus (100, 200 and 400 mg/kg) were studied for its anticonvulsant effect on maximal electroshock induced seizures and metrazol (pentylenetetrazole) induced seizures in rats. Ethanolic extract of Sapindus trifoliatus (100,200 and 400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from metrazole induced tonic seizures.
KEYWORDS:
Sapindus trifoliatus, antiepileptic activity, maximal electric shock, ethanol extract, Metrazol.
Cite:
Jennifer Fernandes, Bhat K.Ishwar, Fernandes Ronald. Screening of Antiepileptic Activity of Leaves of Sapindus trifoliatus Linn. Research J. Pharm. and Tech. 6(10): October 2013; Page 1124-1126.
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