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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  10

Year :  2013

Pages :   1085-1088

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Simple and Sensitive RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium, Ezetimibe and Fenofibrate in Combined Tablet Dosage Form



Address:   Abhijit D. Dhiware, Padmanabh B. Deshpande*, Santosh V. Gandhi, Sujith Nair, Suvarna Vanjari
Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Pune - 411 001, MH, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, accurate, and validated reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous determination of Atorvastatin Calcium, Ezetimibe and Fenofibrate in combined tablet dosage form was developed and validated. Separation was carried out on Jasco HPLC system equipped with HiQ sil C18 HS column (250 × 4.6 mm i.d.) and PDA detector using Methanol: Acetonitrile: 0.02M Ammonium acetate buffer pH adjusted to 10 with Ammonia in ratio of (60:30:10, v/v/v) as the mobile phase and detection was carried out at 240 nm. Results were linear in the range of 0.5-10 Microgram mL-1 for Atorvastatin Calcium and Ezetimibe and 10–60 microgram mL-1 for Fenofibrate. The method was successfully applied for the analysis of drugs in pharmaceutical formulation. Results of the analysis were validated statistically and by recovery studies.
KEYWORDS:
Atorvastain Calcium, Ezetimibe, Fenofibrate, RP-HPLC, Tablet dosage form.
Cite:
Abhijit D. Dhiware, Padmanabh B. Deshpande, Santosh V. Gandhi, Sujith Nair, Suvarna Vanjari. A Simple and Sensitive RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium, Ezetimibe and Fenofibrate in Combined Tablet Dosage Form. Research J. Pharm. and Tech. 6(10): October 2013; Page 1085-1088.
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