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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  1

Year :  2013

Pages :   29-33

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Malabsorption of Drugs in Gastrointestinal Diseases: a Review



Address:   Lakshmi Prasanna J.*, Deepthi B.*, Rama Rao N.
Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Most long term treatments follow the oral administration due to its ease and convenience of administration. After oral administration of any drug, the plasma concentration time curve is a function of many simultaneously operating kinetic processes. The steady state plasma concentration is achieved when the amount of drug absorbed equals the amount of drug eliminated. Both amount and rate of drug absorbed may be altered by diseases which in turn alter other kinetic processes. The amount of drug absorbed is simultaneously affected by physicochemical factors of drug and physiological factors that operate in gut which are also altered by the disease state. The present review focuses on the way in which the absorption of drugs is altered in various conditions of gastro intestinal tract.
KEYWORDS:
Gastric emptying rate, malabsorption, peak plasma concentration, metaclopramide.
Cite:
Lakshmi Prasanna J., Deepthi B., Rama Rao N. Malabsorption of Drugs in Gastrointestinal Diseases: a Review. Research J. Pharm. and Tech. 6(1): Jan. 2013; Page 29-33.
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