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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  9

Year :  2012

Pages :   1229-1234

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Spectrophotometric Method for Analysis of Ziprasidone HCl



Address:   Arun Shirwaikar1, Sarala Devi2, K Premalatha3, Muhammed Maqbool3 and Sreejith K.R.3*
1College of Pharmacy, Gulf Medical University, Ajman, U A E
2Department of Medicine, Pariyaram Medical College, Kannur, India
3Academy of Pharmaceutical Science, Pariyaram Medical College, Kannur, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, precise and sensitive extractive Spectrophotometric method has been described for the assay of Ziprasidone HCl in pure and pharmaceutical preparations. This method is based on the formation of ion-pair complex between the basic nitrogen of the drug with bromothymol blue (BTB) in acidic buffer solution. The formed complex was extracted with chloroform and measured at 415 nm. Beer’s law was obeyed in the range 4-24 µg/ ml with correlation coefficient (n = 6) = 0.9999. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job’s method. The proposed methods have been applied successfully for the analysis of Ziprasidone in pure and in its dosage forms. These developed methods were validated for accuracy and precision.
KEYWORDS:
Ziprasidone, chormophores, spectrophotometry, pharmaceuticals, Bromothymol blue, ion pair.
Cite:
Arun Shirwaikar, Sarala Devi, K Premalatha, Muhammed Maqbool, Sreejith K.R. Development and Validation of Spectrophotometric Method for Analysis of Ziprasidone HCl. Research J. Pharm. and Tech. 5(9): September 2012; Page 1229-1234.
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