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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1076-1080

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Phytochemical, Chromatographic and Hepatoprotective Activity Studies of Indigenous Medicinal plant Coccinia indica



Address:   Sunil Mistry1*, Kunduri Rajeswar Dutt2, Jyotirmoyee Jena3
1Gayatri College of Pharmacy, Gayatri Vihar, Jamadarpali, Sambalpur- 768200, India
2CMR College of Pharmacy, Kandlakoya, Medchan Road, Hyderabad - 501401, India
3Department of Pharmacology, VSS Medical College, Sambalpur University, Sambalpur- 768017, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Coccinia indica (Family: Cucurbitaceae), is widely distributed throughout India. It is used in various indigenous systems of medicine against several diseases and almost every part of the plant has diverse pharmacological properties. The present investigation includes a detailed hepatoprotective activity study of the ethanolic extract of Coccinia indica leaf (CILE) on alcohol induced liver damage in rats. Ethanol produced significant changes in various liver parameters such as physical (increased liver weight and volume) and biochemical (increased levels of AST, ALT, TG, TB and DB) along with changes in histological parameters. Treatments with CILE (200 and 400 mg/kg/day, p.o. for 30 days) and silymarin significantly prevented the physical, biochemical and histological changes induced by ethanol, indicating the recovery of hepatic cells. An optimize HPTLC fingerprint pattern has been developed at 366 nm for the identification and quality assessment of raw leaves of Coccinia indica.
KEYWORDS:
Coccinia indica, HPTLC fingerprinting, hepatoprotective activity, alcohol induced hepatotoxicity.
Cite:
Sunil Mistry, Kunduri Rajeswar Dutt, Jyotirmoyee Jena. Phytochemical, Chromatographic and Hepatoprotective Activity Studies of Indigenous Medicinal plant Coccinia indica. Research J. Pharm. and Tech. 5(8): August 2012; Page 1076-1080.
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