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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1069-1071

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and In-vitro Evaluation of Simvastatin Solid Dispersions



Address:   R.B. Desi Reddy1, T. Neelima Rani1*, S.L. Sindhuri1, P. Bandhavi1, T. Anusha Rani2, Y. Sowjanya2.
1Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli.
2Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the present study was to formulate solid dispersions (SDs) of simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility and therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios was prepared by kneading method. The results showed that simvastatin solubility and dissolution rate was enhanced with polymer PEG4000 in the ratio 1:10 due to increase in wetting property (or) may be due to change in crystallinity of the drug.
KEYWORDS:
Simvastatin, kneading, solid dispersions, PEG, carrier.
Cite:
R.B. Desi Reddy, T. Neelima Rani, S.L. Sindhuri, P. Bandhavi, T. Anusha Rani, Y. Sowjanya. Formulation and In-vitro Evaluation of Simvastatin Solid Dispersions. Research J. Pharm. and Tech. 5(8): August 2012; Page 1069-1071.
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