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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   901-904

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effects of Strychnos potatorum Linn. seeds on Triton WR 1339 Induced Hyperlipidemia in Rats



Address:   Urvi S. Shah1*, K.N. Patel2
1Singhania University, Jhunjhunu, Rajasthan, India.
2SAL Institute of Pharmacy, Ahmadabad, Gujarat, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
We investigated the antihyperlipidemic activity of Strychnos potatorum seeds. The current study was undertaken to assess the hypolipidemic, hypocholesterolemic and hypotriglyceridemic potential of the seeds using triton WR-1339 (Tyloxapol) induced hyperlipidemia in rats. The animals were divided into five groups: control, hyperlipidemic, hyperlipidemic plus Atorvastatin, hyperlipidemic plus Strychnos potatorum seed powder 100mg/kg and Strychnos potatorum seed powder 200mg/kg. Hyperlipidemia was induced by single intraperitoneal injection of triton WR 1339 at a dose of 400mg/kg. Intragastric administration of seed powder significantly (p<0.05) decreased serum total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol levels in rats in dose dependent and time dependent manner compared to hyperlipidemic group. Thus, the findings of the investigation suggest that Strychnos potatorum seeds exhibited quite competitive potential when compared with reference drug Atorvastatin against experimentally induced hyperlipidemia.
KEYWORDS:
Antihyperlipidemic activity, Triton WR 1339, Strychnos potatorum seed, Atorvastatin
Cite:
Urvi S. Shah, K.N. Patel. Effects of Strychnos potatorum Linn. seeds on Triton WR 1339 Induced Hyperlipidemia in Rats. Research J. Pharm. and Tech. 5(7): July 2012; Page 901-904.
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