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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   921-926

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and evaluation of novel bucco-adhesive formulation containing Clotrimazole



Address:   Pramod Shinde*, V. R. Salunkhe, C. S. Magdum
Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present research work support formulation design and evaluation of novel bucco-adhesive thin tablets. This is novel formula contain clotrimazole as an active pharmaceutical ingredient and Eudragit RLPO, carbomer934, PVP K 30 as polymer. Sustained release thin tablet were obtained by direct compression method with high pressure. The tablets were evaluated for applicable parameter as color, odor, taste, size, shape, drug content, weight variation test, swelling index, surface pH, bio-adhesive strength and in vitro release. All the formulation was optimized with respect to bio-adhesive strength and in vitro release rate. The formula F3 containing 10mg Eudragit RLPO, 20mg PVP K30 and 60mg carbomer 934 is found to be suitable for buccal drug delivery system. The optimized formula is appearing as white, thin, suitable, applicable, acceptable and elegant.
KEYWORDS:
Bio-adhesion, Candidiasis, Clotrimazole, modified physical balance, Tween 80.
Cite:
Pramod Shinde, V. R. Salunkhe, C. S. Magdum. Formulation and evaluation of novel bucco-adhesive formulation containing Clotrimazole. Research J. Pharm. and Tech. 5(7): July 2012; Page 921-926.
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