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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   863-867

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Review: Biological Importance of Mercapto Substituted 1,2,4-triazole Derivatives



Address:   N.S. Mahajan1*, A.M. Manikrao1, P.N. Shinde1, R.D. Jawarkar1, P.N. Khatale1, S.C. Dhawale2
1Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur-413307, Maharashtra, India.
2Department of Pharmaceutical Chemistry, SRTM University, Nanded, Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Compounds containing 1,2,4-triazole moiety find wide range of applications and substituted 1,2,4-triazoles are becoming more prevalent in functional materials that are at the cutting edge of new technology. The biological activities of 1,2,4-triazole derivatives are well documented and important discoveries in this area are continued, though the electron donor and coordinating ability of 1,2,4-triazoles has also seen an increase in their use as ligands, functional polymers, and industrial coatings. 1,2,4-triazole has shown its importance as antimicrobial, anti-inflammatory, hypoglycemic, antidepressant, antitubercular, analgesic, antimalarial and anticancer agents. This article is based on different pharmacological activities exhibited by the various compounds containing mercapto and/or thione substituted 1,2,4-triazole heterocyclic ring systems. This review highlighted the basic pharmacophoric requirements for the successful development in the designing of novel antibacterial, antifungal, antitubercular, and anti-inflammatory mercapto triazole agents.
KEYWORDS:
1,2,4-Triazole, Antimicrobial, Antimalarial, Antifungal, Anticancer.
Cite:
N.S. Mahajan, A.M. Manikrao, P.N. Shinde, R.D. Jawarkar, P.N. Khatale, S.C. Dhawale. A Review: Biological Importance of Mercapto Substituted 1,2,4-triazole Derivatives. Research J. Pharm. and Tech. 5(7): July 2012; Page 863-876.
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