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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   809-812

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Mesalazine Solid Dispersion



Address:   Chapalamadugu Ugandhar*
Al-Ameen College of Pharmacy, Bangalore, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple technique of solid dispersion was used in the present investigation. Solid dispersions of mesalazine was prepared by using different carriers such as HPMC K15M and peg 6000. Various solid dispersions were prepared as described in the methodology. Solid state and drug polymer interactions were carried out by UV studies, these studies revealed that drug and polymer were compatible. The dissolution was carried out by USP, basket method. From the results, formulation PEG-1:2 (drug:polymer-1:2) released 87.7% of drug within 8 hours . All the other formulations released were formulated such that they showed enhanced dissolution rate with PEG and HPMC in different ratios. In-vitro release indicated that the solid dispersion containing PEG-1:2 had better dissolution profile when compared with others.
KEYWORDS:
Solid dispersion, PEG, HPMC, dissolution.
Cite:
Chapalamadugu Ugandhar. Formulation and Evaluation of Mesalazine Solid Dispersion. Research J. Pharm. and Tech. 5(6): June 2012; Page 809-812.
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