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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   775-779

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Comparative Evaluation of Disintegrant in Orodispersible Tablet of Aceclofenac



Address:   Himanshu Deshmukh, Chandrashekhara S.*, C. Nagesh, Manish Patil, Vivek Majethiya
Maratha Mandal’s College of Pharmacy, Belgaum-590 016, Karnataka.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The purpose of the present research was to study the effect of using variable quantity of disintegrant agent like Crospovidone, Kyron T314 on the orodispersible property of aceclofenac. Total six formulation having disintegrant at variable amount were prepared by direct compression method. The tablet were assessed if suitable as oral disintegrating tablets by determine of a range of technology parameters. It was observed that the formulation containing Crospovidone have better disintegrating property compared Kyron T314. The wetting time decreased with the increase in concentration of disintegrant. The in vitro dissolution time of various formulation was between 82.13±1.59 to 88.89±1.18 %respectively.
KEYWORDS:
Orodispersible tablets, Kyron T314, Superdisintegrant, wetting time.
Cite:
Himanshu Deshmukh, Chandrashekhara S., C. Nagesh, Manish Patil, Vivek Majethiya. Comparative Evaluation of Disintegrant in Orodispersible Tablet of Aceclofenac. Research J. Pharm. and Tech. 5(6): June 2012; Page 775-779.
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