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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   764-767

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Spectrophotometric Methods for Quantitative Estimation of Pramipexole Dihydrochloride in bulk and Pharmaceutical Dosage Form



Address:   Satish Middi*, Shobha Manjunath
Department of Pharmaceutical Analysis, H.K.E.S’s Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga-585105, Karnataka, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple and sensitive spectrophotometric methods (A and B) in visible region have been developed for the estimation of Pramipexole dihydrochloride in pure and pharmaceutical formulations. Method A and B is based on the condensation of heterocyclic amino group of Pramipexole with Para-dimethyl aminocinnamaldehyde (PDACA) and vanillin in presence of acidic media i.e. conc. Hydrochloride to form a colored chromogen with a characteristic absorption maximum at 525nm and 425nm respectively. Beer's law is obeyed in the concentration range of 50-350µg/mL and 10-50µg/mL for Method A and B respectively. The results obtained with the proposed methods are in good agreement with labeled amounts when the marketed pharmaceutical formulations are analyzed. The results of analysis have been validated statistically and by recovery studies.
KEYWORDS:
Para-dimethylamino cinnamaldehyde, vanillin, Chromogen, Pramipexole, recovery.
Cite:
Satish Middi, Shobha Manjunath. Development and Validation of Spectrophotometric Methods for Quantitative Estimation of Pramipexole Dihydrochloride in bulk and Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 5(6): June 2012; Page 764-767.
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