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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   757-763

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Transdermal Drug Delivery Systems: A Review



Address:   Sweta S. Solanki*, Karan B. Patel, Jalpa G. Patel, Dr. Manish P. Patel, Dr. Jayvadan K. Patel
Department of Pharmaceutics, Nootan Pharmacy College, Visnagar-384315, Gujarat, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Transdermal drug delivery system provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. Transdermal drugs are self-contained, discrete dosage form. Transdermal drug delivery-an approach used to deliver drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Much attention has been given in recent years with regard to the transdermal delivery devices. Broadly this system can be considered as single layer and multilayer. Ficks first law of diffusion is the principle of drug kinetics. Nature and concentration of polymers determines the control of drug release. Drug related factors and physiochemical properties of membranes affects drug penetration. Wide information has been given from drug selection, fabrication to final formulation and various characterizations. Several transdermal applications include hormone replacement therapy, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review includes a brief insight on physiological properties of the skin, several techniques of transdermal drug delivery.
KEYWORDS:
Transdermal Drug Delivery System, Iontophoresis, Electroporation, Sonophoresis, Chemical penetration enhancers, Types of transdermal patch.
Cite:
Sweta S. Solanki, Karan B. Patel, Jalpa G. Patel, Manish P. Patel, Jayvadan K. Patel. Transdermal Drug Delivery Systems: A Review. Research J. Pharm. and Tech. 5(6): June 2012; Page 757-763.
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