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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   687-690

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In-vitro quality control measurement of some commercially available sustained release tablet containing diclofenac sodium



Address:   Tapan Kumar Giri*, Ravikant Sahu, Kulesh Kumar, Amit Alexander, Ajazuddin, Hemant Badwaik, and Dulal Krishna Tripathi
Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491024, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The study assessed the quality of different brand of diclofenac sodium sustained release tablet sourced from medical representative from different pharmaceutical manufacturer in India by evaluating their pharmaceutical and chemical equivalence. The organoleptic and physiochemical properties of these diclofenac sodium tablets were assessed according to established methods. The result of weight variation, swelling study, drug content and drug release of all marketed product comply with established limits. The diclofenac sodium tablet, A exhibited slowest time required to dissolved the 50% of the drug (7.42±0.143 minutes) and lowest value of swelling ratio (0.067±0.015) in 4 hour compared to other tablet. However, tablet showed highest drug content (98.38±0.343) compare to other tablets. Statistical assessment of various in-vitro parameters was also conducted to establish if there were any significance differences among them
KEYWORDS:
Diclofenac sodium, drug content, dissolution, friability, weight variation
Cite:
Tapan Kumar Giri, Ravikant Sahu, Kulesh Kumar, Amit Alexander, Ajazuddin, Hemant Badwaik, and Dulal Krishna Tripathi. In-vitro quality control measurement of some commercially available sustained release tablet containing diclofenac sodium. Research J. Pharm. and Tech. 5(5): May2012; Page 687-690.
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