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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   615-618

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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CNS Depressant Effect of Crude Ethanolic Extract of Flowers of Couroupita guianensis Aubl. in Swiss-albino Mice



Address:   Nowshin Nowaz Rumzhum, Md. Mostafizur Rahman*, AFM Rafiu-Ul Islam
Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Crude ethanolic extract of flowers of Couroupita guianensis Aubl. (Family: Lecythidaceae) was evaluated for central nervous system (CNS) depressant effects using a number of neuropharmacological experimental models in Swiss-albino mice. The extract produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross studies. Further, at the same dose level the extract inhibited acetic acid-induced writhing in mice in dose-dependent manner. These results suggest that the extract possess CNS depressant activity, which support the traditional uses of Couroupita guianensis
KEYWORDS:
Couroupita guianensis Aubl., Lecythidaceae, CNS Depressant effect, Swiss-albino mice.
Cite:
Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam. CNS Depressant Effect of Crude Ethanolic Extract of Flowers of Couroupita guianensis Aubl. in Swiss-albino Mice. Research J. Pharm. and Tech. 5(5): May2012; Page 615-618.
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