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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   538-540

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Modulation of Antioxidant Potential in Liver of Albino rats by seeds of Nelumbo nucifera Gaertn. in 1,4 Dichlorobenzene induced hepato toxicity



Address:   Kanimozhi P.1 and Karthikeyan J.2
1Research Scholar, Department of Biochemistry, Prist University, Thanjavur.
2Scientist cum Assistant Professor, Centre for Research and Development, Prist University, Thanjavur.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
N. nucifera Gaertn Seed Powder was extracted with 50% ethanol, anti oxidant and hepatoprotective activities of the extract was evaluated in 1,4 Dichlorobenzene intoxicated rats. In this study, changes in liver marker enzymes (AST, ALT and ACP) present in serum, antioxidant enzymes (SOD, CAT, GST and GSH) and plasma lipid profile (HDL, LDL, VLDL, TG and Total Cholesterol) were investigated in 1,4 DCB intoxicated rats (300 mg / kg of body wt) to determine its role in toxicity. After treating with 100 mg/kg body wt of N.nucifera Gaertn seed extract, serum enzymes, antioxidant enzymes and plasma lipids return to its normal level in the 1, 4 DCB intoxicated rats. This seed extract showed its best antioxidant potential and liver protective effect like standard drug silymarin.
KEYWORDS:
Nelumbo nucifera Gaertn, Modulation of antioxidant, Hepatotoxicity, 1.4 Dichlorobenzene.
Cite:
Kanimozhi.P, Karthikeyan.J. Modulation of Antioxidant Potential in Liver of Albino rats by seeds of Nelumbo nucifera Gaertn. in 1,4 Dichlorobenzene induced hepato toxicity. Research J. Pharm. and Tech. 5(4): April 2012; Page 538-540.
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