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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   505-512

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and In-Vitro evaluation of Aceclofenac Controlled release tablets by wet granulation method and solid dispersion technique



Address:   T. Venkateswara Rao, Dr. S. Vidyadhara and Dr. K.R.S. Sambasivarao
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt.), Andhra Pradesh. Dept. of Pharmaceutics, Chebrolu Hanumaiah College of Pharmaceutical Sciences, Guntur , Andhra Pradesh.
Dept. of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh. *Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the present study was to develop controlled release matrix tablets of Aceclofenac by wet granulation method and solid dispersion technique using Eudragit RL100 as a rate controlled material. Drug-excipient computability studies were conducted by FT-IR and DSC, results showed no chemical interaction was observed between drug and excipient. The granules were evaluated found free flow properties. The tablets were subjected to thickness, hardness, friability weight variation and in-vitro drug release studies. Results of in vitro drug release studies revealed that drug release was controlled for 12hrs prepared by wet granulation method over the formulations by solid dispersion technique. The drug release pattern followed zero order kinetics and the mechanism of drug release was governed by peppas model. The ā€˜nā€™ values were found to be more than 1 (n>1) which indicated that the drug release was predominately controlled by super case II diffusion.
KEYWORDS:
Aceclofenac, Eudragit RL100 (ERL), solid dispersion, wet granulation, controlled release tablets.
Cite:
T. Venkateswara Rao, Dr. S. Vidyadhara and Dr. K.R.S. Sambasivarao. Formulation and In-Vitro evaluation of Aceclofenac Controlled release tablets by wet granulation method and solid dispersion technique. Research J. Pharm. and Tech. 5(4): April 2012; Page 505-512.
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