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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   494-496

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effective Quantitation of Metronidazole in Injectable Pharmaceutical Dosage Form Using UV Spectroscopy



Address:   Rupali Sanjay Joshi*, Nilima S. Pawar, Sameer Sarvesh Katiyar, Amol Trimbak Shinde, Devendra Bhaskar Zope
Pharmaceutical Chemistry Department, P.D.V.V.P.F’s College of Pharmacy, Vilad – Ghat, Post MIDC, Ahmednagar (M.S.) India 414111
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, rapid, accurate, precise and economical UV spectrophotometric method has been developed for the determination of metronidazole (MET) in pharmaceutical injectable dosage formulation. The method was developed using distilled water as solvent for preparing dilutions. This method obeys Beer’s law in the concentration range of 5-30 microgram/mL with correlation coefficient of 0.999 and exhibiting maximum absorption at 320 nm. The method is accurate and precise as validated and there was no interference from any common pharmaceutical additives and excipients. The results of analysis were validated statistically and by recovery studies. Thus this UV method can be used in the routine quantitative analysis of metronidazole in injectable solutions.
KEYWORDS:
Metronidazole (MET), Interference, UV spectrophotometric method.
Cite:
Rupali Sanjay Joshi, Nilima S. Pawar, Sameer Sarvesh Katiyar, Amol Trimbak Shinde, Devendra Bhaskar Zope. Effective Quantitation of Metronidazole in Injectable Pharmaceutical Dosage Form Using UV Spectroscopy. Research J. Pharm. and Tech. 5(4): April 2012; Page 494-496.
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