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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   474-477

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In-vitro antimitotic activity and antiproliferative activity of different extract of Belanites aegyptiaca



Address:   Katolkar P.P.*, Nimbekar T.P., Wanjari B.E., Nema M.V. and Dongarwar A. S.
Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The main objective of the present work is to investigate the in vitro Anti-mitotic and Anti-proliferative activity of different extract of bark of Belanites aegyptiaca. The Anti-mitotic activity was screened using Allium cepa root meristamatic cells which have been used extensively in screening of drug with antimitotic activity using methotrexate as a standard. The anti-proliferative activity was screened using Yeast as a model system. The methanolic extract showed lowest mitotic index. Methanolic extract have maximum growth inhibition of yeast cells, growth inhibition increases as concentration of extract increases.
KEYWORDS:
Anti-mitotic activity, Anti-proliferative activity, Bark, Belanites aegyptiaca, yeast proteins.
Cite:
Katolkar P.P., Nimbekar T.P., Wanjari B.E., Nema M.V., Dongarwar A. S. In-vitro antimitotic activity and antiproliferative activity of different extract of Belanites aegyptiaca. Research J. Pharm. and Tech. 5(4): April 2012; Page 474-477.
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