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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   462-465

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Delayed Release Formulations of Proton Pump Inhibitors-Similarities and Differences - A Review



Address:   Misam Polara*, Dipil Patel, Musharraf Chauhan, Svapnil Sanghavi, Manish Patel, Jayvadan Patel
Dept. of Pharmaceutics, Nootan Pharmacy College, Visnagar, Gujarat, India, 384315
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Proton-pump inhibitors are acid-labile, and require an enteric coating to protect them from degradation from acid in the stomach when given orally. However, this leads to delayed absorption and onset of action of the proton-pump inhibitor. This article aims to review the comparison among the various formulations of delayed release proton-pump inhibitors. Delayed-release omeprazole and delayed-release lansoprazole have been suspended in sodium bicarbonate for tube administration; however, for omeprazole, absorption is further impaired and antisecretory effects are disappointing. Although such formulations may be more convenient for clinical use in certain patient groups, absorption of the proton-pump inhibitor is still influenced by residual enteric coating. There are few differences among the currently available delayed-release proton-pump inhibitors with respect to their pharmacodynamic effects during chronic administration. There are minor formulation-based pharmacokinetic differences among these agents, primarily reflected in their bioavailability following the first few doses. Differences in bioavailability may explain slight differences in the rate of onset of maximal antisecretory effect. However, minor pharmacodynamic and pharmacokinetic differences are not associated with meaningful differences in clinical outcomes.
KEYWORDS:
Delayed release, Proton-pump inhibitors, Enteric coating, Orally disintegrating, Anti-secretory.
Cite:
Misam Polara, Dipil Patel, Musharraf Chauhan, Svapnil Sanghavi, Manish Patel, Jayvadan Patel. Delayed Release Formulations of Proton Pump Inhibitors-Similarities and Differences - A Review. Research J. Pharm. and Tech. 5(4): April 2012; Page 462-465.
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