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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  3

Year :  2012

Pages :   428-430

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and validation of UV Spectrophotometric method for estimation of milnacipran HCl in bulk and tablet dosage form.



Address:   Nayan C. Ratnakar1*, K. N. Patel2, D. B. Doshi3
1Singhania University, Jhunjhunu, Rajasthan.
2SAL Institute of Pharmacy, Ahmedabad. Gujarat.
3L. M. College of Pharmacy, Ahmedabad, Gujarat.
*Corresponding author’s
DOI No: Not Available

ABSTRACT:
A simple, sensitive, accurate, precise, reproducible, economic spectrophotometric method was developed and validated for the determination of milnacipran hydrochloride in bulk and tablet dosage form. The drug was estimated by using 0.1 N HCl as solvent for this study, which is determined by spectrophotometrically at 223nm. The Beer-lamberts law was obeyed in a concentration range of 2-40 microgram/ml with correlation coefficient of 0.991. The precision and accuracy of the developed method was confirmed by repeatability and recovery studies validated statistically. The LOD and LOQ of milnacipran hydrochloride were found to be 0.41 microgram/ml and 1.24 micrpogram/ml respectively. The percentage recovery study of the drug for the proposed method were found in the range of 100.24-100.79 %. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and sensitive.
KEYWORDS:
Milnacipran HCl; Spectrophotometric analysis; Validation; precision; accuracy; LOD; LOQ.
Cite:
Nayan C. Ratnakar, K. N. Patel, D. B. Doshi. Development and validation of UV Spectrophotometric method for estimation of milnacipran HCl in bulk and tablet dosage form. Research J. Pharm. and Tech. 5(3): Mar.2012; Page 428-430.
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