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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   210-213

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of RP-HPLC Method for Simultaneous Determination of Lisinopril and Amlodipin Besilate in Tablet Dosage Form



Address:   Poonam Bhange1*, Parimal Katolkar1, A.P. Mehere2, T. P. Nimbekar1, B. E. Wanjari1
1M.I.B.P college of Pharmacy, Gondia
2S.P.C.P College of Pharmacy, Wanadongri, Nagpur
Corresponding author
DOI No: Not Available

ABSTRACT:
A simple, sensitive, precise, accurate, rapid, and reproducibility reverse phase high performance liquid chromatography procedure is development for simultaneous determination of lisinopril and amlodipin besilate in solid dosage form the mobile phase use was a combination of acetonitril: buffer (35:65v/v) and the ph was adjusted 7.0 to 0.1 by addition of triethanolamine the detection of solid dosage form tablet was carried out at 266 nm. and flow rate was employed 1ml/min .linearity was obtain in the concentration of range 50-500 of lisinopril and 5-50 of amlodipin with coordination of 0.9999 and 0.9999 the result of analysis were validation statically and recovery study conform the accuracy of proposed method.
KEYWORDS:
RP-HPLC, Amlodipin, Validation.
Cite:
Poonam Bhange, Parimal Katolkar, A.P. Mehere, T. P. Nimbekar, B. E. Wanjari. Development and Validation of RP-HPLC Method for Simultaneous Determination of Lisinopril and Amlodipin Besilate in Tablet Dosage Form. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 210-213.
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