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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   277-280

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Sustain Release Tablet of Salbutamol Sulphate by Wet Granulation Method Using Release Retarding Agent



Address:   Somnath M. Kedar*, Pallavi M. Chaudhari and Rachana N. Patil
Padmashree.Dr . D. Y. Patil College of Pharmacy, Akurdi, Pune, 411044
Corresponding author
DOI No: Not Available

ABSTRACT:
Salbutamol sulphate is an antiasthamatic and bronchodilator agent, with half life of 1.6 hours and requires multiple daily doses to maintain adequate plasma concentrations. The present study was undertaken with an aim to formulate, develop and evaluate Salbutamol sulphate sustained release tablets using ethyl cellulose as release retarding agent. Preformulation study was done initially and results directed for the further course of formulation. Based on preformulation studies different batches of Salbutamol sulphate were prepared using Methocel K100, PVP K30 and Ethyl cellulose. Analysis of Salbutamol sulphate was done by UV visible spectrophometer using wavelength 276nm.From the discussion it was concluded that the tablets of batch F2 had considerable properties and in vitro drug release. Batch F2 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hour release as it fulfils all the requirements for sustained release tablet.
KEYWORDS:
Sustain releasetablets, Methocel K100, PVP K30, Ethyl Cellulose, Salbutamol sulphate.
Cite:
Somnath M. Kedar, Pallavi M. Chaudhari, Rachana N. Patil. Formulation and Evaluation of Sustain Release Tablet of Salbutamol Sulphate by Wet Granulation Method Using Release Retarding Agent. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 277-280.
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