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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   249-252

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis of 1,2,3,4-[ 1-N- Methyl Benzimidazole] 3-Phenyl Substituted Thiazolidine, 4-One and Carbohydrazide Derivatives for Antimicrobial Activity.



Address:   Palled M. S.*., Lohar V. R., Kalekar M. C., Patil P. B., Bhat A. R.
Department of Pharmaceutical Chemistry, K. L.E.U’s College of Pharmacy, Belgaum
Corresponding author
DOI No: Not Available

ABSTRACT:
Research on benzimidazole and thiazolidine-4-one and their synthetic analogs have been revealed to posses wide range of antimicrobial activity. It was our interest to make novel derivatives of fused benzimidazole, thiazolidine-4-one nuclei and evaluate them for antimicrobial activity. Formic acid was treated with o-phenylenediamine to obtain benzimidazole which was treated with CH3I for N-methylation. Later this compound was subjected for Vilsmeier-Haack Reaction, followed by formation of Schiff bases on treatment with various aromatic amines. The various Schiff bases were further treated with thioglycolic acid to obtain thaizolidine-4-one derivatives. (Scheme-I). In another (Scheme-II) N-methyl substituted benzimidazole-2-carbohydrazide (Vilsmeier-Haack Reaction product) followed by acidification, esterification and hydrazide formation. Finally hydrazide treated with different aldehydes to obtain carbohydrazide derivatives. The structures of synthesized derivatives were identified and characterized by m.p, TLC, IR, 1HNMR and Mass Spectroscopy. The synthesized compounds BA-SA, BA-SN, AH-BR and AH-CL have shown significant antibacterial activity against E. coli, E.fecalis, Klebsiella and S. aureus and BA-SA, BA-SN, BA-CL and AH-CL shown significant antifungal activity against C. albicans and A. niger.
KEYWORDS:
Benzimidazole, Thiazolidine-4-one, Carbohydrazide, Antimicrobial activity.
Cite:
Palled M. S.., Lohar V. R., Kalekar M. C., Patil P. B., Bhat A. R. Synthesis of 1,2,3,4-[ 1-N- Methyl Benzimidazole] 3-Phenyl Substituted Thiazolidine, 4-One and Carbohydrazide Derivatives for Antimicrobial Activity. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 249-252.
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