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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1525-1531

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and In vitro Evaluation of Mouth Dissolving Tablets of Carvedilol by Direct Compression Methods



Address:   Abdul Sayeed1*, Md. Hamed M.2, Mohd Rafiq3
1Mesco College of Pharmacy, Hyderabad.
2Department of Pharmacy, NIMS University, Jaipur.
3Shadan college of Pharmacy, Hyderabad.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In the present work, mouth dissolving tablets of Carvedilol were designed with a view to enhance patient compliance, by direct compression methods. In the direct compression method, treated agar was used as disintegarnt. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time. The tablets prepared by direct compression method, formulation TAM3 (containing 2:1 ratio of directly compressible excipient and treated agar) were found to be promising. These formulations were tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40 ± 20 C/75± 5% RH for 3 months) and drug–excipient interaction (IR spectroscopy). Among the promising formulations, the formulation TAM3 prepared by direct compression method emerged as the overall best formulation based on drug release characteristics (in vitro dispersion tome of 12 s and t50% value of 8.51 min) compared to control formulation which shows in vitro dispersion time of 193 s and t50% value of 12.1 min. Short-term stability studies on the promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05). IR-spectroscopic studies indicated that there are no drug–excipient interactions.
KEYWORDS:
Carvedilol, orodispersible tablets, direct compression method, treated agar, directly compressible excipient.
Cite:
Abdul Sayeed, Hamed M., Mohd Rafiq. Formulation and In vitro Evaluation of Mouth Dissolving Tablets of Carvedilol by Direct Compression Methods. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1525-1531.
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