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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1585-1587

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Inflammatory activity of Methanol Extract of the Leaves of Orthosiphon stamineus



Address:   Mrs. C. Maheswari*, Dr. R. Venkatnarayanan , Mr. P. Babu , Dr. D. Benito Jhonson, Siraj Kattuparuthi, Krishna G.
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamil Nadu
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The main objective of the study was to investigate the methanolic extract of leaves of Orthosiphon stamineus against carrageenan induced acute inflammation in Rats. The material was dried in shade, they were powdered and Extracted with methanol. Preliminary phytochemical tests were done. Methanol extract showed presence of phenolic compounds and flavanoids .Albino rats were used for the experiments.Acute anti-inflammatory activity was determined by carrageenan induced paw edema model and Chronic anti inflammatory activity was determined by using Cotton pellet Granuloma model. The extract of the leaves administered orally at a dose 200 mg/kg and 400 mg/kg. The anti-inflammatory activity of methanolic extract of Orthosiphon stamineus was carried out. The Methanol extract significantly inhibited (P<0.05) carrageenan induced paw edema in rat at 400 mg/kg.. The leaves of Orthosiphon stamineus contains flavonoids. Results revealed that the methanol extract of this plant shows the acute anti-inflammatory activity. The activity was attributed to the presence of Flavanoids in the tested extract.
KEYWORDS:
Anti-inflammatory activitiy, Orthosiphon stamineus , Leaves, Carrageenan, Cotton pellet.
Cite:
C. Maheswari, R. Venkatnarayanan, P. Babu, D. Benito Jhonson, Siraj Kattuparuthi, Krishna G. Anti-Inflammatory activity of Methanol Extract of the Leaves of Orthosiphon stamineus. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1585-1587.
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