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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1573-1576

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Hyperglycemic activity of the Leaves of Terminalia tomentosa against Normal and Alloxan Induced Diabetic Rats



Address:   Saroj Kumar Raul1*, B.V.V Ravi kumar2, Ajaya Kumar Pattnaik3: 1M. R. College of Pharmacy, Phool-Baugh, Vizianagaram, A.P, India.: 2Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India.: 3Departments of Chemistry, Ravenshaw University, Cuttack, Orissa, India.: *Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the study is to investigate the alcoholic (AlcE) and aqueous (Aq) extracts of leaves of Terminalia tomentosa (Combretaceae) leaves for hypoglycemic effects in normal and diabetic rats. Crude aqueous (Aq) and alcoholic (AlcE) extracts of the leaves of T. tomentosa were administered to both normal and alloxan (120 mg/ kg, i.p.) or by injecting dexamethasone (10 mg/kg, i.p.) induced diabetic male albino rats (Wister strain). AlcE and Aq had significantly decreased the blood-glucose level (BGL) in a dose-dependent manner after repeated administration for seven days. In alloxan-induced diabetic rats, both the extracts decreased blood sugar levels with significant improvement in glucose tolerance and body weight at the end of 1st, 2nd and 3rd week after the test extract treatment. In case of dexamethasone induced insulin resistant diabetic rats, repeated administration of AlcE and Aq inhibited the increase in blood glucose level and improved glucose tolerance induced by dexamethasone as compared to dexamethasone induced diabetic rats. These results suggest that both extracts possess hypoglycemic activity in normal as well as in diabetic rats.
KEYWORDS:
Terminalia tomentosa , hypoglycaemic effect , Alloxan , dexamethasone.
Cite:
Sravanthi.Alladi, Sarath Prakash D., Ramesh Malothu, Nalini M., Srikanth Rao K. Anti-Hyperglycemic activity of the Leaves of Terminalia tomentosa against Normal and Alloxan Induced Diabetic Rats. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1573-1576.
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