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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  11

Year :  2012

Pages :   1446-1451

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis of Substituted Fluoroindole as an Anti-Bacterial Agent



Address:   N. S. Devshetwar1, L.V.G. Nargund1*, Nirmal T. Havannavar2, Shachindra L. Nargund3
1Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II main,100Ft ring Road, BSK II stage, Bangalore- 560085 (India).
2Professor and Head, Dept. of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar.
3Dept of Chemistry, Texas State University, San Marco, USA.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Indole containing organic compounds forms a significant class of drugs which exhibit an array of biological activities ranging from antibacterial, antifungal, anti-inflammatory, antipyretic to CNS depressants and anticancer. The present work aimed to synthesize novel 1-(6-Chloro-5-fluoro-3-phenyl-1H-indol-2-yl)-ethanone derivative with a desire to obtain potent antibacterial activity. The synthesized derivatives are characterized by Melting point, TLC, IR and 1H NMR spectra and then compounds are screened in-vitro antibacterial activity.
KEYWORDS:
Fluoroindole, anti-bacterial activity, Indoles.
Cite:
N. S. Devshetwar, L.V.G. Nargund, Nirmal T. Havannavar, Shachindra L. Nargund. Synthesis of Substituted Fluoroindole as an Anti-Bacterial Agent. Research J. Pharm. and Tech. 5(11):November, 2012; Page 1446-1451.
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