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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In vitro anticancer activity of Ethanolic and Aqueous Extracts of Peristrophe bivalvis Merrill.



Address:   *Assistant Professor, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 1Vice Principal and H.O.D. Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli. 2Principal and H.O.D, Pharmaceutics, Appasaheb Birnale College of Pharmacy,
DOI No: Not Available

ABSTRACT:
In present study in vitro anticancer activity of ethanolic and aqueous extracts of leaves and stems of Peristrophe bivalvis Merrill was evaluated. In vitro anticancer activity was assayed by tryphan blue dye exclusion method and brine shrimp lethality bioassay method. Extracts were found to be cytotoxic in dose dependent manner in both methods. Ethanolic extract was found to be potent than aqueous extract. Leaves showed more significant anticancer activity as compared to stems. The CTC50 of ethanolic extract of leaves was found to be 175.25±12.34 µg/ml in EAC cell lines. The LC50 of ethanolic extract of leaves was176.49±7.43 µg/ml. It indicated that Peristrophe bivalvis Merrill has potential to prevent cancer in a dose dependent manner.
KEYWORDS:
Peristrophe bivalvis Merrill, Cytotoxicity, anticancer, Ehrlich ascites carcinoma (EAC) cells.
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