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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of UV Spectrophotometric Method for Estimation of Amlodipine Besylate in Tablet Dosage Form



Address:   1Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli. 2Narasaraopet Institute of Pharmaceutical Sciences, Yellamanda, Narasaraopet.
DOI No: Not Available

ABSTRACT:
A new Ultra-violet Spectroscopic method was developed and validated for the determination of amlodipine besylate in tablet dosage form. The sample was analysed using methanol buffer. The λmax values for amlodipine besylate in the solvent medium was found to be 281 nm. The system obey Beer’s law and shows linearity in the range of 5-30µg/ml.% Recovery studies, Intra-day and interday precision were found to be 98.8%,99.98% and 99.99%. No interference was observed from common tablet adjuvants. The changes in the λmax values (Physical parameter) for amlodipine besylate was evaluated as for stability study. The method was successfully applied to the assay of amlodipine besylate in tablet formulation. The proposed method is fast, accurate and precise for the determination of amlodipine besylate for routine quality control of tablets.
KEYWORDS:
Amlodipine besylate, Methanol buffer, Beer’s law, Precision, UV Spectroscopy.
Cite:
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