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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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High Performance Thin Layer Chromatographic Determination of Metoprolol Succinate and Olmesartan in Combined Capsule Dosage Form



Address:   Department of Pharmaceutical Analysis, AISSMS College of Pharmacy, Kennedy Road, Near R. T. O., Pune–411001
DOI No: Not Available

ABSTRACT:
This paper describes a new simple High Performance Thin Layer Chromatographic (HPTLC) method for determination of Metoprolol succinate and Olmesartan in combined capsule dosage form has been developed and validated. The mobile phase selected was n- butanol and Methanol (6:3, v/v) with UV detection at 225 nm. The retention factor for Metoprolol succinate and Olmesartan were found to be 0.23 ± 0.02 and 0.65 ± 0.05, respectively. The method was validated with respect to linearity, accuracy, precision and robustness as per the International Conference on Harmonisation (ICH) guidelines. Results found to be linear in the concentration range of 250-2500 ng band -1 for Metoprolol succinate and 100-1000 ng band -1 for Olmesartan. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 100.09 ± 0.97 for Metoprolol succinate and 100.54 ± 0.80 for Olmesartan.
KEYWORDS:
Metoprolol Succinate, Olmesartan, HPTLC, Capsule dosage form.
Cite:
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