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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and antibacterial activity of some new (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, Derivatives of Chalcone.

Address:   1Maharashtra Academy of Engineering And Educational Research’s , Maharashtra Institute of Pharmacy S.No.124, MIT Campus, Paud Road, Pune- 411038,M.S.,India. 2Department of Chemistry, University of Pune, Pune- 411007, M.S., India. 3J.S.P.M.’s Jayawan
DOI No: Not Available

Present work describes the synthesis of (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, derivatives of Chalcones. Starting material 8- hydroxy quinoline was acetylated and subjected to fries rearrangement reaction to yield 7-acetaldehyde-8-hydroxy quinoline which on aldol condensation with various derivatives of benzaldehyde yields 13 compounds. The compounds have been characterized and evaluated for anti-bacterial activity. MIC values of the compounds showing higher zone of inhibition was found to be 100 µg/ml. The activity of the compounds can be attributed to the substitution of electronegative groups in the synthesized compounds.
anti-bacterial activity, benzaldehyde, Chalcone, electronegative, 8-hydroxyquinoline
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