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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Scolicidal Activity of some Potential Prodrugs of Albendazole



Address:   1Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, BP 6203, Rabat Institute, University Mohammed V Souissi, Rabat, Morocco. 2Laboratory of Parasitology-Mycology, Instruction Military Hospital Mohammed V, Rabat, Morocco. 3Research Cent
DOI No: Not Available

ABSTRACT:
The treatment of hydatidosis is primarily surgical but can cause morbidity or mortality, hence the interest in many cases of medical treatment whose main representative is albendazole. The efficacy of this compound against Echinococcus granulosus cysts is proved, but limited by its poor bioavailability. New potential prodrugs were synthesized and their protoscolicidal activity was tested in vitro. Although hydrogen N°1 is important for the albendazole activity, some derivatives have kept an activity relatively important.
KEYWORDS:
Echinococcus granulosus, Albendazole, synthesis, protoscolicidal activity, hydatid cyst.
Cite:
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