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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Hepatoptotective Activity of Ixora javanica D.C. Flowers against CCl4-induced Liver Damage in Rats


K. Hemalatha*, K. Priya Darsini and D. Sunitha

Email ID Not Available

Address:   Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally- 500 014. Secunderabad, Andhra Pradesh. India
DOI No: Not Available

ABSTRACT:
Materials and Methods: In the present study, the ethyl acetate and ethanolic extracts from the flowers of Ixora javanica were studied against CCl4-induced hepatotoxicity in rats. Result: Ethyl acetate and ethanolic extracts at a dose of 200 and 400 mg/Kg body weight , p. o. offered significant (P<0.001) hepatoptrotective action by reducing the serum marker enzymes like SGPT, SGOT, ALP, biliribin and cholesterol in test doses which was comparable with that of the standard silymarin. The ethyl acetate and ethanolic extract was able to restore the biochemical levels to normal which were altered due to CCl4 intoxication in freshly isolated rat hepatocytes and also in animals. Conclusion: The results indicate that Ixora javanica flowers could be useful in preventing chemically induced acute liver injury.
KEYWORDS:
CCl4- induced liver damage, Ixora javanica flowers, hepatoprotective.
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