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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antiepileptic Effects of Sapindus mukorossi in rats



Address:   SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
DOI No: Not Available

ABSTRACT:
Plant for the present studies was selected on the bases of literature review. Plant was collected from local market Bilaspur, Chhattisgarh, The collected leaves were powdered in grinder and extracts were prepared in ethanol and chloroform solvents. These extracts were used for further studies. Phytochemical studies had been performed on the extracts and it was found to have like saponin, Sterols, Fatty acids and oils and carbohydrate. Acute oral toxicity study of ethanolic extract of Sapindus mukorossi (EESM) was conducted in rat by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight. In Maximal electro-shock (MES) induced model, dose of EESM (200 and 400mg/kg) show highly significant anticonvulsant activity, but dose of chloroform extract of Sapindus mukorossi (CESM) did not show any anticonvulsant activity as compared to control group. In Pentylenetetrazol (PTZ) model lower dose of EESM (200 and 400mg/kg) show good anticonvulsant activity as compared to control group. Locomotor study in actophotomotor extract of EESM exhibited the decreased motor activity in dose dependent manner, it is sign of sedation. ESM increase the threshold of MES induced convulsion in a dose dependent manner.
KEYWORDS:
Sapindus mukorossi, Pentylenetetrazol, Maximal electro-shock, Diazepam and Phenytoin.
Cite:
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