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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   63-67

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Hemorrhoidal Activity of Leaf Extract of Adenia lobata (Jacq.) Engl. (Passifloraceae)



Address:   Konkon N’dri Gilles1,2, Adjoungoua Attoli Léopold1, Ouattara Djakalia2, Simaga Dédéou1, Koné Bamba1, N’guessan Kouakou Edouard2 and Kouakou Tanoh Hilaire3*
1Laboratoire de Pharmacognosie, UFR des Sciences Pharmaceutiques et Biologiques, Université Cocody
01 BP V 34 Abidjan 01, Côte d’Ivoire
2Laboratoire de Botanique, UFR Biosciences, Université Cocody, 22 BP 1414 Abidjan 22, Côte d’Ivoire
3 Laboratoire de Biologie et d’Amélioration des Productions Végétales, UFR Sciences de la Nature, Université
d’Abobo-Adjamé, 02 BP 801 Abidjan 02, Côte d’Ivoire.
Corresponding author
DOI No: Not Available

ABSTRACT:
Next to modern therapeutic, many plants resulting from the African traditional pharmacopeia are used by the traditional healers as anti-hemorrhoidal remedies. The aim of this study was to evaluate the anti-hemorrhoidal activity of leaves of Adenia lobata. This work has focused on the inflammatory aspect of the hemorrhoid. Induction of inflammation was made with kaolin mixed with arabic gum. Solutions of A. lobata leaves used with preventive measure delay the inflammatory process of hemorrhoidal disease and for curative cure hemorrhoidal inflammation. Also, the anti-inflammatory activity observed is due to flavonoids present in leaves of A. lobata. Preparation of solutions with cool water is more effective than that carried out with the hot water which denatures the active ingredients of the remedy. At the doses used, this remedy is deprived of acute toxicity and can be taken safety by patients. A six times higher solution concentration than that of the traditional healer gives a similar anti-inflammatory response to it. Thus, there is a minimum concentration of A. lobata leaves solutions from which the anti-inflammatory effect is maximal. The anti-hemorrhoidal action of leaves of A. lobata was established and tests on veinotonic aspect are in progress.
KEYWORDS:
Adenia lobata; anti-hemorrhoidal activity; Côte d’Ivoire; leaf; traditional healer.
Cite:
Konkon N’dri Gilles, Adjoungoua Attoli Léopold, Ouattara Djakalia, Simaga Dédéou, Koné Bamba, N’guessan Kouakou Edouard, Kouakou Tanoh Hilaire. Anti-Hemorrhoidal Activity of Leaf Extract of Adenia lobata (Jacq.) Engl. (Passifloraceae). Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 63-67.
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