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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   46-49

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Spectrophotometric Assay for the Simultaneous Analysis of Mifepristone and Misoprostol in Tablets Using Vierodt’s and Absorbance Ratio Methods



Address:   Devadasu C.H.*, Harika S., Mallikarjuna T., Adilakshmi G., Sreenath A. and Swetha Ratna G.
Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur-522 213, AP, India.
Corresponding author
DOI No: Not Available

ABSTRACT:
Two simple, accurate and rapid methods have been developed for the quantitative determination of mifepristone and misoprostol in their dosage form. Method-I is based on constructing and solving two simultaneous equations at 304nm and 257.6nm for mifepristone and misoprostol respectively. In the quantitative assay of two components in admixture by the absorbance ratio method, absorbances are measured at 264.6nm (iso-absorptive point) and 304nm (Method-II). These two methods were validated in terms of linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. The linearity was in the concentration range of 8-24µg/ml for both the methods.
KEYWORDS:
Mifepristone, Misoprostol, Simultaneous equations, Absorbance ratio, Spectrophotometry.
Cite:
Devadasu C.H., Harika S., Mallikarjuna T., Adilakshmi G., Sreenath A., Swetha Ratna G. A Spectrophotometric Assay for the Simultaneous Analysis of Mifepristone and Misoprostol in Tablets Using Vierodt’s and Absorbance Ratio Methods. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 46-49.
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